Publications

- Girault A, Ahidouch A, Ouadid-Ahidouch H. Roles for Ca2+ and K+ channels in cancer cells exposed to the hypoxic tumour microenvironment. Biochim Biophys Acta Mol Cell Res. 2020 Jan 10;1867(4):118644. doi: 10.1016/j.bbamcr.2020.118644. [Epub ahead of print] Review. PMID:31931022
- Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A. Rev Physiol Biochem Pharmacol. Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. 2020 Aug 7. doi: 10.1007/112_2020_19. Online ahead of print. PMID: 32761457
- Foulon A., Theret P, Rodat-Despoix L, Kischel P. Beyond chemotherapies : Recent strategies in breast cancer treatment. Cancers (Basel). 2020 Sep 16;12(9):2634. doi: 10.3390/cancers12092634.
- Nicolas JONCKHEERE, Julie AUWERCX, Elsa HADJ BACHIR, Lucie COPPIN, Nihad BOUKROUT, Audrey VINCENT, Bernadette NEVE, Mathieu GAUTIER, Victor TREVINO, Isabelle VAN SEUNINGEN.
- Unsupervised hierarchical clustering of pancreatic adenocarcinoma dataset from TCGA defines a mucin expression profile that impacts overall survival.
  Cancers (In Press)
- Lefebvre T, Rybarczyk P, Bretaudeau C, Vanlaeys A, Cousin R, Brassart-Pasco S, Chatelain D, Dhennin-Duthille I, Ouadid-Ahidouch H, Brassart B, Gautier M.
  TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration.
  Front Cell Dev Biol. 2020 Jul 8;8:549. doi: 10.3389/fcell.2020.00549. eCollection 2020. PMID: 32733880
- Vanlaeys A, Fouquet G, Kischel P, Hague F, Pasco-Brassart S, Lefebvre T, Rybarczyk P, Dhennin-Duthille I, Brassart B, Ouadid-Ahidouch H, Gautier M. Cadmium exposure enhances cell migration and invasion through modulated TRPM7 channel expression.
  Arch Toxicol.
- Peretti M, Badaoui M, Girault A, Van Gulick L, Mabille MP, Tebbakha R, Sevestre H, Morjani H, Ouadid-Ahidouch H. Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership. Sci Rep. 2019 Feb 4;9(1):1175. doi: 10.1038/s41598-018-37602-7.PMID:30718673
- Brassart B, Da Silva J, Donet M, Seurat E, Hague F, Terryn C, Velard F, Michel J, Ouadid-Ahidouch H, Monboisse JC, Hinek A, Maquart FX, Ramont L, Brassart-Pasco S. Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA. Br J Cancer. 2019 Feb;120(4):453-465. doi: 10.1038/s41416-019-0382-0. Epub 2019 Feb. PMID:30739912
- Kischel P, Girault A, Rodat-Despoix L, Chamlali M, Radoslavova S, Abou Daya H, Lefebvre T, Foulon A, Rybarczyk P, Hague F, Dhennin-Duthille I, Gautier M, Ouadid-Ahidouch H. Ion Channels: New Actors Playing in Chemotherapeutic Resistance. Cancers (Basel). 2019 Mar 16;11(3). pii: E376. doi: 10.3390/cancers11030376. Review.PMID:30884858
- Caulier A, Jankovsky N, Demont Y, Ouled-Haddou H, Demagny J, Guitton C, Merlusca L, Lebon D, Vong P, Aubry A, Lahary A, Rose C, Gréaume S, Cardon E, Platon J, Ouadid-Ahidouch H, Rochette J, Marolleau JP, Picard V, Garçon L. PIEZO1 activation delays erythroid differentiation of normal and Hereditary Xerocytosis-derived human progenitors. Haematologica. 2019 Aug 14. pii: haematol.2019.218503. doi: 10.3324/haematol.2019.218503. [Epub ahead of print]PMID:31413092
- Bressand D, Novell A, Girault A, Raoul W, Fromont-Hankard G, Escoffre JM, Lecomte T, Bouakaz A. Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model. Mol Pharm. 2019 Sep 3;16(9):3814-3822. doi: 10.1021/acs.molpharmaceut.9b00416. Epub 2019 Aug 6.PMID: 31356090
- Gautier M, Trebak M, Fleig A, Vandier C, Ouadid-Ahidouch H. Ca2+ channels in cancer. Cell Calcium. 2019 Dec;84:102083. doi: 10.1016/j.ceca.2019.102083. Epub 2019 Sep 26. No abstract available. PMID:31606459
- Gautier M, Trebak M, Fleig A, Vandier C, Ouadid-Ahidouch H. Ca2+ homeostasis and cancer. Cell Calcium. 2019 Dec;84:102084. doi: 10.1016/j.ceca.2019.102084. Epub 2019 Sep 26. No abstract available. PMID:31593838
- Luongo F, Pietropaolo G, Gautier M, Dhennin-Duthille I, Ouadid-Ahidouch H, Wolf FI, Trapani V. TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.
  Nutrients. 2018 Jun 18;10(6). pii: E784. doi: 10.3390/nu10060784. PMID:29912157
- Vautrin-Glabik A, Botia B, Kischel P, Ouadid-Ahidouch H, Rodat-Despoix L. IP3R3 silencing induced actin cytoskeletal reorganization through ARHGAP18/RhoA/mDia1/FAK pathway in breast cancer cell lines.
  Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):945-958. doi: 10.1016/j.bbamcr.2018.04.002. Epub 2018 Apr 7.PMID:29630900
- Hasna J, Hague F, Rodat-Despoix L, Geerts D, Leroy C, Tulasne D, Ouadid-Ahidouch H, Kischel P. Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection.
  Cell Death Differ. 2018 Mar;25(4):691-705. doi: 10.1038/s41418-017-0007-1. Epub 2018 Jan 11. PMID:29323264
- Badaoui M, Mimsy-Julienne C, Saby C, Van Gulick L, Peretti M, Jeannesson P, Morjani H, Ouadid-Ahidouch H. Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway.
  Oncotarget. 2017 Jul 8;9(37):24653-24671. doi: 10.18632/oncotarget.19065. eCollection 2018 May 15. PMID: 29872495
- Da Silva J, Lameiras P, Beljebbar A, Berquand A, Villemin M, Ramont L, Dukic S, Nuzillard JM, Molinari M, Gautier M, Brassart-Pasco S, Brassart B. Structural characterization and in vivo pro-tumor properties of a highly conserved matrikine.
  Oncotarget. 2018 Apr 3;9(25):17839-17857. doi: 10.18632/oncotarget.24894. eCollection 2018 Apr 3. PMID: 29707150
- Rybarczyk P, Vanlaeys A, Brassart B, Dhennin-Duthille I, Chatelain D, Sevestre H, Ouadid-Ahidouch H, Gautier M. The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway.
  Neoplasia. 2017 Apr;19(4):288-300. doi: 10.1016/j.neo.2017.01.004. Epub 2017 Mar 8.
  PMID:28284058
- Mound A, Vautrin-Glabik A, Foulon A, Botia B, Hague F, Parys JB, Ouadid-Ahidouch H, Rodat-Despoix L. Downregulation of type 3 inositol (1,4,5)-trisphosphate receptor decreases breast cancer cell migration through an oscillatory Ca2+ signal. Oncotarget. 2017 Aug 18;8(42):72324-72341. doi: 10.18632/oncotarget.20327. eCollection 2017 Sep 22.
  PMID:29069790
- Gueder N, Allan G, Telliez MS, Hague F, Fernandez JM, Sanchez-Fernandez EM, Ortiz-Mellet C, Ahidouch A, Ouadid-Ahidouch H. sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.
  J Cell Physiol. 2017 Dec;232(12):3631-3640. doi: 10.1002/jcp.25832. Epub 2017 Apr 25.
  PMID:28145580
- Charles E, Hammadi M, Kischel P, Delcroix V, Demaurex N, Castelbou C, Vacher AM, Devin A, Ducret T, Nunes P, Vacher P. The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload.
  Oncotarget. 2017 Jan 10;8(2):3181-3196. doi: 10.18632/oncotarget.13689.
  PMID:27911858
- Mignen O, Constantin B, Potier-Cartereau M, Penna A, Gautier M, Guéguinou M, Renaudineau Y, Shoji KF, Félix R, Bayet E, Buscaglia P, Debant M, Chantôme A, Vandier C. Constitutive calcium entry and cancer: updated views and insights. Eur Biophys J. 2017 Jul;46(5):395-413. doi: 10.1007/s00249-017-1216-8. Epub 2017 May 17. Review. PMID:28516266
- Gautier M, Perrière M, Monet M, Vanlaeys A, Korichneva I, Dhennin-Duthille I, Ouadid-Ahidouch H.Curr Recent Advances in Oncogenic Roles of the TRPM7 Chanzyme. Med Chem. 2016;23(36):4092-4107.PMID:27604090
- Benzerdjeb N, Sevestre H, Ahidouch A, Ouadid-Ahidouch H. Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma.
  Oncotarget. 2016 Dec 6;7(49):81588-81597. doi: 10.18632/oncotarget.13149. PMID:27835593
- Pan Z, Choi S, Ouadid-Ahidouch H, Yang JM, Beattie JH, Korichneva I. Zinc transporters and dysregulated channels in cancers. Front Biosci (Landmark Ed). 2017 Jan 1;22:623-643. Review. PMID:27814637
- Faouzi M, Hague F, Geerts D, Ay AS, Potier-Cartereau M, Ahidouch A, Ouadid-Ahidouch H. Functional cooperation between KCa3.1 and TRPC1 channels in human breast cancer: Role in cell proliferation and patient prognosis.
  Oncotarget. 2016 Jun 14;7(24):36419-36435. doi: 10.18632/oncotarget.9261. PMID: 27183905
- Ouadid-Ahidouch H, Ahidouch A, Pardo LA. Kv10.1 K(+) channel: from physiology to cancer. Pflugers Arch. 2016 May;468(5):751-62. doi: 10.1007/s00424-015-1784-3. Epub 2016 Jan 8. Review. PMID:26743871
- Ouadid-Ahidouch H, Rodat Despoix L, Matifat F, Morin G, Ahidouch A. DNA methylation of channel-related genes in cancers. Biochim Biophys acta. 2015 Feb 20.pii:S0005-2736(15)00055-3.doi:10.1016/j.bbamem.2015.02.015. Epub ahead of print] Review. PMID: 25703813
- Bulk E, Ay AS, Hammadi M, Ouadid-Ahidouch H, Schel has S, Hascher A, Rohde C, Thoennis sen NH, Wiewrodt R, Schmidt E, Marra A, Hillejan, L, Jacobs AH, Klein HU, Dugas M, Berdel WE, Müller-Tidow C, Schwab A.
  Epigentic dysregulation of K Ca3.1 channels induces poor prognosis in lung cancer.
  Int J Cancer.2015 Feb 20.doi/10.1002/ijc.29490. [Epub ahead of print] PMID: 25704182
- Cai C, Lin P, Zhu H, Ko JK, Hwang M, Tan T, Pan Z, Korichneva I, Ma J. Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane.
  J Biol Chem. 2015 Apr 13. pii: jbc.M114.620690. [Epub ahead of print]
  PMID: 25869134
- Lolignier S, Bonnet C, Gaudioso C, Noël J, Ruel J, Amsalem M, Ferrier J, Rodat-Despoix L, Bouvier V, Aissouni Y, Prival L, Chapuy E, Padilla F, Eschalier A, Delmas P, Busserolles J. The nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.
  Cell Rep. 2015 May 19;11(7):1067-78. doi: 10.1016/j.celrep.2015.04.027. Epub 2015 May 7.
  PMID: 25959819
- Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A.
  Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.
  ChemMedChem. 2015 Dec;10(12):2014-26. doi: 10.1002/cmdc.201500360. Epub 2015 Oct 5.
  PMID:26434977
- Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
  Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29.
  PMID:26360047